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Dr Veena Aggarwal, Consultant Womens’ Health, CMD and Editor-in-Chief, IJCP Group & Medtalks Trustee, Dr KK’s Heart Care Foundation of India 02 January 2023
The US FDA has expanded the indications of abaloparatide to also include men with osteoporosis at high risk of fracture or intolerant to or in case of failure of other treatments. Abaloparatide is a parathyroid hormone related peptide [PTHrP(1-34)] analog and is available as Tymlos. The approval has been granted on the basis of the phase 3 ATOM (Abaloparatide Treatment of Men) study.1-3
Abaloparatide is already FDA-approved (in 2017) for use in postmenopausal osteoporotic women at high risk of fracture/s or those in whom other anti-osteoporotic treatments have failed.
Dose and administration: 80ug subcutaneously once daily into the periumbilical region of abdomen. Ensure calcium and vitamin D supplementation in cases of insufficient dietary consumption.
Contraindications: Known hypersensitivity to abaloparatide
Adverse effects (in men): Local injection site reactions (such as erythema, swelling pain, contusion); nausea, diarrhea, abdominal distension, abdominal pain, dizziness, arthralgia, bone pain.
Warnings and precautions
References
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